BSI PD ISO/TR 19057:2017
$198.66
Nanotechnologies. Use and application of acellular in vitro tests and methodologies to assess nanomaterial biodurability
| Published By | Publication Date | Number of Pages |
| BSI | 2017 | 58 |
This document reviews the use and application of acellular in vitro tests and methodologies implemented in the assessment of the biodurability of nanomaterials and their ligands in simulated biological and environmental media.
This document is intended to focus more on acellular in vitro methodologies implemented to assess biodurability and, therefore, excludes the general review of relevant literature on in vitro cellular or animal biodurability tests.
PDF Catalog
| PDF Pages | PDF Title |
|---|---|
| 2 | National foreword |
| 7 | Foreword |
| 9 | 1 Scope 2 Normative references 3 Terms and definitions |
| 10 | 4 Symbols and abbreviated terms |
| 12 | 5 Background including need for assessing the biodurability of particles |
| 14 | 6 Aims and objectives 7 Approaches for assessment of micrometre mineral particle and fibre biodurability 7.1 General |
| 15 | 7.2 Dissolution of nanomaterials versus their dispersion and biodegradation 8 Need for the assessment of nanomaterial biodurability |
| 16 | 9 Influence of different types of ligands and coatings on nanomaterial biodurability 10 Review of methodologies to assess micrometre mineral particle and fibre biodurability 10.1 General 10.2 In vitro acellular methods |
| 17 | 10.3 Description of different simulated physiological media 10.3.1 General 10.3.2 Simulated lung airway lining fluids |
| 18 | 10.3.3 Simulated lung macrophage phagolysosomal fluid 10.3.4 Digestive system (saliva, gastric and intestinal fluids) |
| 19 | 10.3.5 Simulated sweat (SSW) 10.4 Description of different simulated environmental media 10.4.1 General 10.4.2 Simulated natural freshwaters 10.4.3 Simulated seawater 10.4.4 Simulated estuarine waters 10.5 Description of different test systems to assess dissolution of particles and fibres 10.5.1 General |
| 20 | 10.5.2 Static dissolution system 10.5.3 Continuous flow system (CFS) 10.5.4 Batch and batch filter systems 10.5.5 Tangential flow filtration system |
| 21 | 10.6 Assessment of dissolved mass concentration post dissolution experiment 10.6.1 General 10.6.2 Techniques based on physical principles |
| 22 | 10.6.3 Techniques based on mechanical concepts |
| 23 | 10.6.4 Techniques based on chemical principles |
| 24 | 10.6.5 Ultraviolet-visible (UV-Vis) spectroscopy 10.6.6 One-dimensional mathematical models 10.6.7 Single particle inductively coupled plasma-mass spectrometry (spICP-MS) |
| 25 | 11 Calculation of micrometre mineral particle biodurability 11.1 General |
| 26 | 11.2 Dissolution kinetics, dissolution rates, and dissolution rate constants 11.3 Dissolution kinetics and dissolution rate of larger particles and fibres |
| 28 | 11.4 Dissolution kinetics and dissolution rate of nanoparticles 11.5 Assessment of halftime estimates of particles and fibres |
| 29 | 11.6 Assessment of lifetime estimates for particles and fibres 11.6.1 General 11.6.2 Shrinking sphere theory |
| 30 | 11.6.3 Shrinking fibre theory |
| 31 | 11.7 Assessment of halftime and lifetime estimates |
| 32 | 12 Examples of micrometer mineral particles and fibres where biodurability was assessed using in vitro acellular systems 12.1 Glass and asbestos fibres 12.2 Silicon dioxide (SiO2) |
| 33 | 12.3 Talc 12.4 Tungsten oxide 12.5 Beryllium 13 Examples of nanomaterials where biodurability was assessed using in vitro acellular systems 13.1 SWCNTs and MWCNTs |
| 34 | 13.2 Silver nanoparticles (AgNPs) 13.3 Titanium dioxide (TiO2) 13.4 Zinc oxide (ZnO) |
| 35 | 14 Biodurability of ligands 14.1 General 14.2 Examples of ligands attached to particles where biodurability has been assessed 14.3 Methodologies to assess the biodurability of the attached ligands 14.3.1 General 14.3.2 Gel permeation chromatography (GPC) |
| 36 | 14.3.3 Matrix-assisted laser desorption ionization mass spectrometer (MALDI-MS) 14.3.4 Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) 14.3.5 Liquid chromatography coupled with mass spectrometry (LC-MS/MS) 15 Relationship with relevant international documents 15.1 Simulated sweat |
| 37 | 15.2 Simulated sebum 15.3 Simulated lung fluids 15.4 Simulated digestive system fluids 16 Assessing the validity of assay/test systems |
| 38 | 17 Biological relevance of the dissolution assay |
| 39 | 18 Use of biodurability tests in risk assessment and its limitations |
| 40 | Annex A (informative) Tables of relevant information |
| 44 | Bibliography |
